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MKP-8 / DUSP26 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9BV47 |
| Reactivity | Human, Rabbit, Hamster, Monkey, Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24kDa |
| Dilution | IHC-P (20 µg/ml) |
| Gene ID | 78986 |
|---|---|
| Other Names | Dual specificity protein phosphatase 26, 3.1.3.16, 3.1.3.48, Dual specificity phosphatase SKRP3, Low-molecular-mass dual-specificity phosphatase 4, DSP-4, LDP-4, Mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, Novel amplified gene in thyroid anaplastic cancer, DUSP26, DUSP24, LDP4, MKP8, NATA1, SKRP3 |
| Target/Specificity | Human DUSP26. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | MKP-8 / DUSP26 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DUSP26 |
|---|---|
| Synonyms | DUSP24, LDP4, MKP8, NATA1, SKRP3 |
| Function | Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). |
| Cellular Location | Cytoplasm. Nucleus. Golgi apparatus. |
| Tissue Location | Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
References
Vasudevan S.A.,et al.Biochem. Biophys. Res. Commun. 330:511-518(2005).
Yu W.,et al.Oncogene 26:1178-1187(2007).
Takagaki K.,et al.Mol. Cell. Biochem. 296:177-184(2007).
Zama T.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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