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CALCRL / CGRP Receptor Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q16602 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53kDa |
| Dilution | IHC-P (16 µg/ml) |
| Gene ID | 10203 |
|---|---|
| Other Names | Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CALCRL, CGRPR |
| Target/Specificity | Human CALCRL. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | CALCRL / CGRP Receptor Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CALCRL (HGNC:16709) |
|---|---|
| Synonyms | CGRPR |
| Function | G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:33602864). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed:32296767, PubMed:9620797). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32296767, PubMed:8626685). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Predominantly expressed in the lung and heart. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
References
Aiyar N.,et al.J. Biol. Chem. 271:11325-11329(1996).
Fluehmann B.,et al.Biochem. Biophys. Res. Commun. 206:341-347(1995).
Kopatz S.A.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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