GRM6 / MGLUR6 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | O15303 |
Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Pig, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 95kDa |
Dilution | IHC-P (12 µg/ml) |
Gene ID | 2916 |
---|---|
Other Names | Metabotropic glutamate receptor 6, mGluR6, GRM6, GPRC1F, MGLUR6 |
Target/Specificity | Human GRM6 / MGLUR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM7 (73%), GRM4 (67%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | GRM6 / MGLUR6 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GRM6 |
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Synonyms | GPRC1F, MGLUR6 |
Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane |
Tissue Location | Detected in melanocytes. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
References
Hashimoto T.,et al.Eur. J. Neurosci. 9:1226-1235(1997).
Schmutz J.,et al.Nature 431:268-274(2004).
Devi S.,et al.Pigment Cell Melanoma Res. 26:348-356(2013).
Dryja T.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:4884-4889(2005).
Sjoeblom T.,et al.Science 314:268-274(2006).
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