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> home > Products > Primary Antibodies > Antibody Collections > Chemokine signaling > GRK5 Antibody (N-Terminus)
GRK5 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
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Application 
| IHC-P |
|---|---|
| Primary Accession | P34947 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 68kDa |
| Dilution | IHC-P (6 µg/ml) |
| Gene ID | 2869 |
|---|---|
| Other Names | G protein-coupled receptor kinase 5, 2.7.11.16, G protein-coupled receptor kinase GRK5, GRK5, GPRK5 |
| Target/Specificity | Human GRK5. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRK1 (47%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GRK5 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRK5 |
|---|---|
| Synonyms | GPRK5 |
| Function | Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). |
| Cellular Location | Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion |
| Tissue Location | Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney. |
| Volume | 50 µl |
Research Areas
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$ 467.50
Cat# ALS10666
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