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ADGRV1 / GPR98 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q8WXG9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 693kDa |
| Dilution | IHC-P (15 µg/ml) |
| Gene ID | 84059 |
|---|---|
| Other Names | G-protein coupled receptor 98, Monogenic audiogenic seizure susceptibility protein 1 homolog, Usher syndrome type-2C protein, Very large G-protein coupled receptor 1, GPR98, KIAA0686, KIAA1943, MASS1, VLGR1 |
| Target/Specificity | Human GPR98. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except LAMC2 (53%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | ADGRV1 / GPR98 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADGRV1 (HGNC:17416) |
|---|---|
| Function | G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8VHN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VHN7}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q8VHN7} Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHN7} Note=Localizes at the ankle region of the stereocilia. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex. {ECO:0000250|UniProtKB:Q8VHN7} |
| Tissue Location | Expressed at low levels in adult tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor that may have an important role in the development of the central nervous system.
References
Nikkila H.,et al.Mol. Endocrinol. 14:1351-1364(2000).
McMillan D.R.,et al.J. Biol. Chem. 277:785-792(2002).
Schmutz J.,et al.Nature 431:268-274(2004).
Nagase T.,et al.DNA Res. 8:319-327(2001).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
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