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GPR88 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - GPR88 Antibody (Internal) ALS10399
    Anti-GPR88 antibody ALS10399 IHC of human thymus.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9GZN0
Reactivity Human, Mouse, Rabbit, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 40kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 54112
Other Names Probable G-protein coupled receptor 88, Striatum-specific G-protein coupled receptor, GPR88, STRG
Target/Specificity Human GPR88. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR88 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR88
Synonyms STRG
Function Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (PubMed:35501348). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (PubMed:23936473). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (PubMed:23936473).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q9ESP4}; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q9ESP4}. Nucleus {ECO:0000250|UniProtKB:Q9ESP4}. Note=Localized to cilia in ciliated cells; whereas in non-ciliated cells, distributed throughout the cell membrane (PubMed:23936473). During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood {ECO:0000250|UniProtKB:Q9ESP4, ECO:0000269|PubMed:23936473}
Tissue Location Expressed predominantly in the striatum.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Orphan receptor.

References

Mizushima K.,et al.Genomics 69:314-321(2000).
Kopatz S.A.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 467.50
Cat# ALS10399
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