CXCR5 Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P32302 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 42kDa |
Dilution | IHC-P (5-18 µg/ml) |
Gene ID | 643 |
---|---|
Other Names | C-X-C chemokine receptor type 5, CXC-R5, CXCR-5, Burkitt lymphoma receptor 1, Monocyte-derived receptor 15, MDR-15, CD185, CXCR5, BLR1, MDR15 |
Target/Specificity | Human CXCR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MTA3 (50%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | CXCR5 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CXCR5 |
---|---|
Synonyms | BLR1, MDR15 |
Function | Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Expression in mature B-cells and Burkitt lymphoma cells |
Volume | 50 µl |
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Background
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
References
Dobner T.,et al.Eur. J. Immunol. 22:2795-2799(1992).
Barella L.,et al.Biochem. J. 309:773-779(1995).
Legler D.F.,et al.J. Exp. Med. 187:655-660(1998).
Sjoeblom T.,et al.Science 314:268-274(2006).
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