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GPR34 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
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  • IHC - GPR34 Antibody (C-Terminus) ALS10317
    Anti-GPR34 antibody IHC of human Soft Tissue, Liposarcoma.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9UPC5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 44kDa
Dilution IHC-P (1 µg/ml)
Additional Information
Gene ID 2857
Other Names Probable G-protein coupled receptor 34, GPR34
Target/Specificity Human GPR34. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR82 (100%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR34 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR34
Function G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:16460680). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Broadly expressed. Highly expressed on mast cells (PubMed:16460680).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Orphan receptor.

References

Schoneberg T.,et al.Biochim. Biophys. Acta 1446:57-70(1999).
Marchese A.,et al.Genomics 56:12-21(1999).
Jacobi F.K.,et al.Hum. Genet. 107:89-91(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 467.50
Cat# ALS10317
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