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GPR34 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9UPC5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44kDa |
| Dilution | IHC-P (1 µg/ml) |
| Gene ID | 2857 |
|---|---|
| Other Names | Probable G-protein coupled receptor 34, GPR34 |
| Target/Specificity | Human GPR34. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR82 (100%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GPR34 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR34 |
|---|---|
| Function | G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:16460680). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Broadly expressed. Highly expressed on mast cells (PubMed:16460680). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor.
References
Schoneberg T.,et al.Biochim. Biophys. Acta 1446:57-70(1999).
Marchese A.,et al.Genomics 56:12-21(1999).
Jacobi F.K.,et al.Hum. Genet. 107:89-91(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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