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GRM1 / MGLUR1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q13255 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 132kDa |
| Dilution | IHC-P (2 µg/ml) |
| Gene ID | 2911 |
|---|---|
| Other Names | Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1 |
| Target/Specificity | Human GRM1 / MGLUR1, isoform alpha. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GRM1 / MGLUR1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRM1 |
|---|---|
| Synonyms | GPRC1A, MGLUR1 |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (PubMed:24357660, PubMed:27276689). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in brain.. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
References
Desai M.A.,et al.Mol. Pharmacol. 48:648-657(1995).
Stephan D.,et al.Neuropharmacology 35:1649-1660(1996).
Mungall A.J.,et al.Nature 425:805-811(2003).
Guergueltcheva V.,et al.Am. J. Hum. Genet. 91:553-564(2012).
Wu H.,et al.Science 344:58-64(2014).
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