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CALCR / Calcitonin Receptor Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P30988 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59kDa |
| Dilution | IHC-P (9.2 µg/ml) |
| Gene ID | 799 |
|---|---|
| Other Names | Calcitonin receptor, CT-R, CALCR |
| Target/Specificity | Human Calcitonin Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | CALCR / Calcitonin Receptor Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CALCR (HGNC:1440) |
|---|---|
| Function | G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed:35324283, PubMed:38603770). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively (PubMed:35324283, PubMed:38603770). IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes (PubMed:35324283, PubMed:38603770). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35324283, PubMed:7476993). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
References
Gorn A.H.,et al.J. Clin. Invest. 90:1726-1735(1992).
Kuestner R.E.,et al.Mol. Pharmacol. 46:246-255(1994).
Albrandt K.,et al.Endocrinology 136:5377-5384(1995).
Frendo J.L.,et al.FEBS Lett. 342:214-216(1994).
Nishikawa T.,et al.FEBS Lett. 458:409-414(1999).
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