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S1PR5 / EDG8 / S1P5 Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9H228 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42kDa |
| Dilution | IHC-P (4-7 µg/ml) |
| Gene ID | 53637 |
|---|---|
| Other Names | Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8, S1PR5, EDG8 |
| Target/Specificity | Human S1PR5 / EDG8. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except DKK3 (61%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | S1PR5 / EDG8 / S1P5 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | S1PR5 |
|---|---|
| Synonyms | EDG8 |
| Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
References
Kothapalli R.,et al.Biochim. Biophys. Acta 1579:117-123(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Im D.-S.,et al.Biochemistry 40:14053-14060(2001).
Kopatz S.A.,et al.Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
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