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NUCB1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q63083 |
| Other Accession | NM_053463.1, NP_445915 |
| Reactivity | Mouse, Rat, Dog |
| Predicted | Mouse, Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54kDa |
| Gene ID | 84595 |
|---|---|
| Alias Symbol | Nucb |
| Other Names | Nucleobindin-1, Bone 63 kDa calcium-binding protein, CALNUC, Nucb1, Nuc |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-NUCB1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | NUCB1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Nucb1 |
|---|---|
| Synonyms | Nuc |
| Function | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (PubMed:7890746). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (PubMed:21653697). |
| Cellular Location | Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Lumenal side. Cytoplasm. Secreted Note=A small fraction of the protein may be cytoplasmic. In bone at least part of it is found in the extracellular matrix and in the culture medium of calvaria explants. |
| Tissue Location | Minor constituent of the mineralized matrix of bone. Detected in calvaria, rib cartilage, liver, kidney, spleen, brain, lung, skeletal and heart muscle with highest expression in calvaria and approximately half the amount in kidney, liver and brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis.
References
Wendel M.,et al.J. Biol. Chem. 270:6125-6133(1995).
Long X.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Adams L.A.,et al.Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
Lin P.,et al.J. Cell Biol. 141:1515-1527(1998).
Lin P.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:674-679(2000).
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