DRG1 Antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9Y295 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 40kDa |
Gene ID | 4733 |
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Alias Symbol | DRG1, NEDD3, |
Other Names | Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, NEDD-3, DRG1, NEDD3 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-DRG1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | DRG1 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DRG1 {ECO:0000303|PubMed:29915238, ECO:0000312|HGNC:HGNC:3029} |
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Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:23711155, PubMed:29915238, PubMed:37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). |
Cellular Location | Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes |
Tissue Location | High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.
References
Zhao X.-F.,et al.Biochim. Biophys. Acta 1448:109-114(1998).
Li B.,et al.Biochim. Biophys. Acta 1491:196-204(2000).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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