TSPYL5 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q86VY4 |
Other Accession | NP_277047 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 45kDa |
Gene ID | 85453 |
---|---|
Alias Symbol | TSPYL5, KIAA1750, |
Other Names | Testis-specific Y-encoded-like protein 5, TSPY-like protein 5, TSPYL5, KIAA1750 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-TSPYL5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | TSPYL5 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TSPYL5 |
---|---|
Synonyms | KIAA1750 |
Function | Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.
References
Nagase T.,et al.DNA Res. 7:347-355(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Kim E.J.,et al.Biochem. Biophys. Res. Commun. 392:448-453(2010).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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