PMPCA Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q10713 |
Other Accession | NM_015160, NP_055975 |
Reactivity | Human, Mouse, Rat, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 54kDa |
Gene ID | 23203 |
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Alias Symbol | Alpha-MPP, INPP5E |
Other Names | Mitochondrial-processing peptidase subunit alpha, 3.4.24.64, Alpha-MPP, P-55, PMPCA, INPP5E, KIAA0123, MPPA |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-PMPCA antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | PMPCA Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PMPCA |
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Synonyms | INPP5E, KIAA0123, MPPA |
Function | Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. |
Cellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:P20069}. Mitochondrion inner membrane |
Tissue Location | Ubiquitously expressed with highest expression in fetal tissues and adult brain, cerebellum and cerebellar vermis |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cleaves presequences (transit peptides) from mitochondrial protein precursors.
References
Nagase T.,et al.DNA Res. 2:37-43(1995).
Nagase T.,et al.DNA Res. 2:167-174(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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