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WDR43 Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - WDR43 Antibody - N-terminal region AI15629

    Host: Rabbit
    Target Name: WDR43
    Sample Tissue: 721_B Whole Cell lysates
    Antibody Dilution: 1.0μg/ml
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q15061
Other Accession NP_055946
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 74kDa
Additional Information
Gene ID 23160
Alias Symbol WDR43, KIAA0007, UTP5,
Other Names WD repeat-containing protein 43, WDR43, KIAA0007, UTP5
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-WDR43 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsWDR43 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDR43 (HGNC:28945)
Synonyms KIAA0007, UTP5
Function Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity).
Cellular Location Nucleus, nucleolus. Nucleus, nucleolus fibrillar center. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6ZQL4}
Citations (0)
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References

Nomura N.,et al.DNA Res. 1:27-35(1994).
Scherl A.,et al.Mol. Biol. Cell 13:4100-4109(2002).
Olsen J.V.,et al.Cell 127:635-648(2006).
Beausoleil S.A.,et al.Nat. Biotechnol. 24:1285-1292(2006).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 389.00
Cat# AI15629
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