THOP1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P52888 |
Other Accession | NM_003249, NP_003240 |
Reactivity | Human |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 76kDa |
Gene ID | 7064 |
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Alias Symbol | EP24.15, MEPD_HUMAN, MP78, TOP |
Other Names | Thimet oligopeptidase, 3.4.24.15, Endopeptidase 24.15, MP78, THOP1 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-THOP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | THOP1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | THOP1 |
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Function | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P47788}. |
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Provided below are standard protocols that you may find useful for product applications.
References
Thompson A.,et al.Biochem. Biophys. Res. Commun. 213:66-73(1995).
Taylor G.R.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Papastoitsis G.,et al.Biochemistry 33:192-199(1994).
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