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SCUBE3 Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - SCUBE3 Antibody - N-terminal region AI15350

    WB Suggested Anti-SCUBE3 Antibody Titration: 1.0 μg/ml
    Positive Control: MCF7 Whole Cell
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q8IX30
Other Accession NM_152753, BAC03798
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 96kDa
Additional Information
Gene ID 222663
Alias Symbol CEGF3, DKFZp686B09105, DKFZp686B1223, DKFZp686D20108, FLJ34743
Other Names Signal peptide, CUB and EGF-like domain-containing protein 3, SCUBE3 (HGNC:13655)
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-SCUBE3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSCUBE3 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCUBE3 (HGNC:13655)
Function Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors (PubMed:33308444). It is required for ligand-induced recruitment of BMP receptors to lipid rafts (By similarity). Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Cellular Location Secreted. Cell surface
Tissue Location Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up- regulated in lung cancer cells.
Research Areas
Citations (0)
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References

Wu B.-T.,et al.J. Biol. Chem. 279:37485-37490(2004).
Pfarr N.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 389.00
Cat# AI15350
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