TBXAS1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P24557 |
Other Accession | NM_001061, NP_001052 |
Reactivity | Human |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 61kDa |
Gene ID | 6916 |
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Alias Symbol | CYP5, CYP5A1, FLJ52771, GHOSAL, THAS, TS, TXAS, TXS, BDPLT14 |
Other Names | Thromboxane-A synthase, TXA synthase, TXS, 5.3.99.5, Cytochrome P450 5A1, TBXAS1, CYP5, CYP5A1 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TBXAS1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | TBXAS1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TBXAS1 |
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Synonyms | CYP5, CYP5A1 {ECO:0000303|PubMed:1146554 |
Function | Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, PubMed:24009185, PubMed:8436233, PubMed:9873013). Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12- HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:22735388, PubMed:9873013). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy- (5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. |
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Provided below are standard protocols that you may find useful for product applications.
References
Yokoyama C.,et al.Biochem. Biophys. Res. Commun. 178:1479-1484(1991).
Ohashi K.,et al.J. Biol. Chem. 267:789-793(1992).
Miyata A.,et al.Eur. J. Biochem. 224:273-279(1994).
Shen R.-F.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Chevalier D.,et al.Mutat. Res. 432:61-67(2001).
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