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CD207 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UJ71 |
| Other Accession | NM_015717, NP_056532 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig |
| Predicted | Mouse, Rat, Pig, Horse, Bovine, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36kDa |
| Gene ID | 50489 |
|---|---|
| Alias Symbol | CLEC4K |
| Other Names | C-type lectin domain family 4 member K, Langerin, CD207, CD207, CLEC4K |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CD207 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CD207 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD207 |
|---|---|
| Synonyms | CLEC4K |
| Function | Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. |
| Cellular Location | Membrane; Single- pass type II membrane protein. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes |
| Tissue Location | Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Valladeau J.,et al.Immunity 12:71-81(2000).
Hillier L.W.,et al.Nature 434:724-731(2005).
Stambach N.S.,et al.Glycobiology 13:401-410(2003).
Valladeau J.,et al.Immunol. Res. 28:93-107(2003).
de Witte L.,et al.Nat. Med. 13:367-371(2007).
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