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CD68 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - CD68 antibody - N-terminal region AI14906

    WB Suggested Anti-CD68 Antibody Titration: 1.0 μg/ml
    Positive Control: NCI-H226 Whole Cell
    detail
  • WB - CD68 antibody - N-terminal region AI14906

    Host:Rabbit
    Target Name:CD68
    Sample Tissue:Human 293T
    Antibody Dilution: 1.0μg/ml
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P34810
Other Accession NM_001251, NP_001242
Reactivity Human, Horse, Bovine
Predicted Human, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Additional Information
Gene ID 968
Alias Symbol DKFZp686M18236, GP110, SCARD1, LAMP4
Other Names Macrosialin, Gp110, CD68, CD68
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CD68 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCD68 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD68
Function Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Cellular Location [Isoform Short]: Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
Research Areas
Citations (0)
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References

Holness C.L.,et al.Blood 81:1607-1613(1993).
Kalnine N.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).

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$ 389.00
Cat# AI14906
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