MAGEF1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9HAY2 |
Other Accession | NM_022149, NP_071432 |
Reactivity | Human, Rabbit, Pig, Bovine, Dog |
Predicted | Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 34kDa |
Gene ID | 64110 |
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Alias Symbol | MGC19617 |
Other Names | Melanoma-associated antigen F1, MAGE-F1 antigen, MAGEF1 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-MAGEF1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | MAGEF1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MAGEF1 (HGNC:29639) |
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Function | Enhances ubiquitin ligase activity of RING-type zinc finger- containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034). |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
References
Stone B.,et al.Gene 267:173-182(2001).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Chomez P.,et al.Cancer Res. 61:5544-5551(2001).
Doyle J.M.,et al.Mol. Cell 39:963-974(2010).
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