ENTPD5 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O75356 |
Other Accession | NM_001249, NP_001240 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 47kDa |
Gene ID | 957 |
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Alias Symbol | CD39L4, MGC163357, MGC163359, NTPDase-5, PCPH |
Other Names | Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, 3.6.1.6, CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, 3.6.1.42, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, UDPase ENTPD5, ENTPD5, CD39L4, PCPH |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ENTPD5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | ENTPD5 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ENTPD5 (HGNC:3367) |
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Function | Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10400613, PubMed:15698960). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP- glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity). |
Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9WUZ9}. Secreted |
Tissue Location | Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues |
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Provided below are standard protocols that you may find useful for product applications.
References
Chadwick B.P.,et al.Genomics 50:357-367(1998).
Recio J.A.,et al.Mol. Carcinog. 27:229-236(2000).
Murphy-Piedmonte D.M.,et al.Biochim. Biophys. Acta 1747:251-259(2005).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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