RAB2A antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P61019 |
Other Accession | NM_002865, NP_002856 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 23kDa |
Gene ID | 5862 |
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Alias Symbol | RAB2, LHX |
Other Names | Ras-related protein Rab-2A, RAB2A, RAB2 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RAB2A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | RAB2A antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RAB2A (HGNC:9763) |
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Synonyms | RAB2 |
Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (Probable). Together with RAB2B redundantly required for efficient autophagic flux (PubMed:28483915). |
Cellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor; Cytoplasmic side Melanosome. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P53994}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P53994}; Lipid-anchor; Cytoplasmic side Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250|UniProtKB:P53994, ECO:0000269|PubMed:17081065} |
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Provided below are standard protocols that you may find useful for product applications.
References
Tachibana K.,et al.Nucleic Acids Res. 16:10368-10368(1988).
Zahraoui A.,et al.J. Biol. Chem. 264:12394-12401(1989).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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