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FCRL5 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q96RD9 |
| Other Accession | NM_031281, NP_112571 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 106kDa |
| Gene ID | 83416 |
|---|---|
| Alias Symbol | BXMAS1, CD307, DKFZp667E2019, DKFZp667F216, FCRH5, FLJ00333, FLJ00397, IRTA2, MGC119590, MGC119592, MGC119593, PRO820 |
| Other Names | Fc receptor-like protein 5, FcR-like protein 5, FcRL5, BXMAS1, Fc receptor homolog 5, FcRH5, Immune receptor translocation-associated protein 2, CD307e, FCRL5, FCRH5, IRTA2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-FCRL5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | FCRL5 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FCRL5 |
|---|---|
| Synonyms | FCRH5, IRTA2 |
| Function | Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (PubMed:30107486). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Nakayama Y.,et al.Biochem. Biophys. Res. Commun. 285:830-837(2001).
Hatzivassiliou G.,et al.Immunity 14:277-289(2001).
Davis R.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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