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CYP2W1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8TAV3 |
| Other Accession | NM_017781, NP_060251 |
| Reactivity | Human, Rat, Pig, Horse, Bovine, Dog |
| Predicted | Human, Pig, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54kDa |
| Gene ID | 54905 |
|---|---|
| Alias Symbol | MGC34287 |
| Other Names | Cytochrome P450 2W1, 1.14.14.-, CYPIIW1, CYP2W1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CYP2W1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CYP2W1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CYP2W1 {ECO:0000303|PubMed:26936974, ECO:0000312|HGNC:HGNC:20243} |
|---|---|
| Function | A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4- hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974). Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:22591743, PubMed:26936974). May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:20805301, PubMed:24278521). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974). |
| Cellular Location | Endoplasmic reticulum lumen. Cell membrane. Microsome membrane. Note=About 8% are expressed on the cell surface. |
| Tissue Location | Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Hillier L.W.,et al.Nature 424:157-164(2003).
Karlgren M.,et al.Biochem. Biophys. Res. Commun. 341:451-458(2006).
Wu Z.L.,et al.Mol. Pharmacol. 69:2007-2014(2006).
Gomez A.,et al.Mol. Pharmacol. 78:1004-1011(2010).
Eun C.Y.,et al.Toxicol. Res. 26:171-175(2010).
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$ 389.00
Cat# AI14565
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