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> home > Products > Primary Antibodies > Antibody Collections > Cytokine > IL21 Antibody - C-terminal region
IL21 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9HBE4 |
| Other Accession | NM_001207006, NP_001193935 |
| Reactivity | Human, Pig, Goat, Sheep, Horse, Bovine, Dog |
| Predicted | Human, Pig, Goat, Sheep, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16kDa |
| Gene ID | 59067 |
|---|---|
| Alias Symbol | IL-21, Za11 |
| Other Names | Interleukin-21, IL-21, Za11, IL21 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-IL21 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | IL21 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL21 (HGNC:6005) |
|---|---|
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes |
Research Areas
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$ 389.00
Cat# AI14555
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