SCO1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O75880 |
Reactivity | Human |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 33kDa |
Gene ID | 6341 |
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Alias Symbol | SCO1, SCOD1, |
Other Names | Protein SCO1 homolog, mitochondrial, SCO1, SCOD1 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-SCO1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | SCO1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SCO1 |
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Synonyms | SCOD1 |
Function | Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT- CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity). |
Cellular Location | Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein |
Tissue Location | Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain. |
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Provided below are standard protocols that you may find useful for product applications.
References
Petruzzella V.,et al.Genomics 54:494-504(1998).
Horvath R.,et al.Biochem. Biophys. Res. Commun. 276:530-533(2000).
Peng Y.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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