GCET2 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q8N6F7 |
Other Accession | NM_152785, NP_689998 |
Reactivity | Human |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 21kDa |
Gene ID | 257144 |
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Alias Symbol | GCAT2, HGAL, MGC40441, GCET2 |
Other Names | Germinal center-associated signaling and motility protein, Germinal center B-cell-expressed transcript 2 protein, Germinal center-associated lymphoma protein, hGAL, GCSAM, GAL, GCET2 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-GCET2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | GCET2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GCSAM |
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Synonyms | GAL, GCET2 |
Function | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. |
Cellular Location | Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6 |
Tissue Location | Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen |
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Provided below are standard protocols that you may find useful for product applications.
References
Pan Z.,et al.Am. J. Pathol. 163:135-144(2003).
Lossos I.S.,et al.Blood 101:433-440(2003).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Natkunam Y.,et al.Blood 105:3979-3986(2005).
Lu X.,et al.Blood 110:4268-4277(2007).
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