SLC30A8 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q8IWU4 |
Other Accession | NM_173851, NP_776250 |
Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Dog |
Predicted | Human, Rabbit, Pig, Chicken, Horse, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 41kDa |
Gene ID | 169026 |
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Alias Symbol | ZnT-8, ZNT8 |
Other Names | Zinc transporter 8, ZnT-8, Solute carrier family 30 member 8, SLC30A8, ZNT8 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SLC30A8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | SLC30A8 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC30A8 (HGNC:20303) |
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Function | Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. |
Cellular Location | Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Associated with insulin and glucagon secretory granules. |
Tissue Location | In the endocrine pancreas, expressed in insulin- producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive |
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