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ST6GALNAC6 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q969X2 |
| Other Accession | NM_013443, NP_038471 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rabbit, Pig, Horse, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38kDa |
| Gene ID | 30815 |
|---|---|
| Alias Symbol | RP11-203J24.3, SIAT7F, ST6GALNACVI |
| Other Names | Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 6, 2.4.99.-, GalNAc alpha-2, 6-sialyltransferase VI, ST6GalNAc VI, ST6GalNAcVI, hST6GalNAc VI, Sialyltransferase 7F, SIAT7-F, ST6GALNAC6, SIAT7F |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ST6GALNAC6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ST6GALNAC6 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST6GALNAC6 |
|---|---|
| Synonyms | SIAT7F |
| Function | Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3- linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity). |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
| Tissue Location | Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. |
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Senda,M.,(2007)Biochem.J.402(3),459-470ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
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$ 389.00
Cat# AI12730
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