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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > SF3A3 antibody - middle region
SF3A3 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q12874 |
| Other Accession | NM_006802, NP_006793 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Yeast, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59kDa |
| Gene ID | 10946 |
|---|---|
| Alias Symbol | PRP9, PRPF9, SAP61, SF3a60 |
| Other Names | Splicing factor 3A subunit 3, SF3a60, Spliceosome-associated protein 61, SAP 61, SF3A3, SAP61 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SF3A3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SF3A3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SF3A3 |
|---|---|
| Synonyms | SAP61 |
| Function | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). |
| Cellular Location | Nucleus speckle. Nucleus |
| Tissue Location | Ubiquitous.. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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$ 389.00
Cat# AI11784
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