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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > CPNE1 antibody - N-terminal region
CPNE1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q99829 |
| Other Accession | NM_003915, NP_003906 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rabbit, Pig, Chicken, Sheep, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59kDa |
| Gene ID | 8904 |
|---|---|
| Alias Symbol | CPN1, COPN1 |
| Other Names | Copine-1, Copine I, CPNE1, CPN1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-CPNE1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CPNE1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPNE1 (HGNC:2314) |
|---|---|
| Synonyms | CPN1 |
| Function | Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium- dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:19539605, PubMed:9430674). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium- independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). |
| Cellular Location | Nucleus. Cytoplasm. Cell membrane Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385). |
| Tissue Location | Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Tomsig,J.L., Biochem. J. 378 (PT 3), 1089-1094 (2004)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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$ 339.00
Cat# AI11758
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