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SF3B1 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • IHC - SF3B1 antibody - N-terminal region AI11711
    Rabbit Anti-SF3B1 Antibody
    Paraffin Embedded Tissue: Human Liver
    Cellular Data: Hepatocytes
    Antibody Concentration: 4.0-8.0 μg/ml
    Magnification: 400X
    detail
  • IHC - SF3B1 antibody - N-terminal region AI11711
    Rabbit Anti-SF3B1 Antibody
    Paraffin Embedded Tissue: Human Skin
    Cellular Data: Epidermal cells
    Antibody Concentration: 16 μg/ml
    Magnification: 400X
    detail
  • IHC - SF3B1 antibody - N-terminal region AI11711
    Rabbit Anti-SF3B1 Antibody
    Paraffin Embedded Tissue: Human alveolar cell
    Cellular Data: Epithelial cells of renal tubule
    Antibody Concentration: 4.0-8.0 μg/ml
    Magnification: 400X
    detail
  • WB - SF3B1 antibody - N-terminal region AI11711

    WB Suggested Anti-SF3B1 Antibody Titration: 1.25μg/ml
    Positive Control: Human Thymus
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession O75533
Other Accession NM_012433, NP_036565
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Goat, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 143kDa
Additional Information
Gene ID 23451
Alias Symbol PRP10, SAP155, SF3b155, MDS, Hsh155, PRPF10
Other Names Splicing factor 3B subunit 1, Pre-mRNA-splicing factor SF3b 155 kDa subunit, SF3b155, Spliceosome-associated protein 155, SAP 155, SF3B1, SAP155
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-SF3B1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSF3B1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SF3B1 {ECO:0000303|PubMed:30567737, ECO:0000312|HGNC:HGNC:10768}
Function Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity).
Cellular Location Nucleus. Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm
Research Areas
Citations (0)
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References

Beausoleil,S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 339.00
Cat# AI11711
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