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Ppargc1a antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O70343 |
| Other Accession | NM_008904, NP_032930 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rabbit, Pig, Goat, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 90kDa |
| Gene ID | 19017 |
|---|---|
| Alias Symbol | A830037N07Rik, PGC-1, PGC-1v, Pgc-1alpha, Pgc1, Pgco1, Ppargc1, Gm11133, ENSMUSG00000079510 |
| Other Names | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, Ppargc1a, Pgc1, Pgc1a, Ppargc1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ppargc1a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Ppargc1a antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ppargc1a |
|---|---|
| Synonyms | Pgc1, Pgc1a, Ppargc1 |
| Function | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:12754525). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (By similarity). Also involved in the integration of the circadian rhythms and energy metabolism (PubMed:17476214). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (PubMed:17476214). |
| Cellular Location | Nucleus. Nucleus, PML body |
| Tissue Location | White quadriceps and red tibialis anterior (TA) muscles, liver, kidney and brown adipose tissue (at protein level) Skeletal muscle, brown adipose tissue, heart, kidney and brain |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Finck,B.N. (2006) J. Clin. Invest. 116 (3), 615-622Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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$ 389.00
Cat# AI11678
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