CBLL1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q75N03 |
Other Accession | NM_024814, NP_079090 |
Reactivity | Human, Mouse, Rat, Rabbit |
Predicted | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 54kDa |
Gene ID | 79872 |
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Alias Symbol | FLJ23109, HAKAI, MGC163401, MGC163403, RNF188 |
Other Names | E3 ubiquitin-protein ligase Hakai, 6.3.2.-, Casitas B-lineage lymphoma-transforming sequence-like protein 1, RING finger protein 188, c-Cbl-like protein 1, CBLL1, HAKAI, RNF188 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CBLL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | CBLL1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CBLL1 (HGNC:21225) |
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Function | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). |
Cellular Location | Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm {ECO:0000250|UniProtKB:Q9JIY2}. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus {ECO:0000250|UniProtKB:Q9JIY2} |
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Provided below are standard protocols that you may find useful for product applications.
References
Ota,T., J. Cell. Sci. 117 (PT 7), 989-998 (2004)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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