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MCM3 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - MCM3 antibody - C-terminal region AI11009

    WB Suggested Anti-MCM3 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: 721_B cell lysate
    MCM3 is supported by BioGPS gene expression data to be expressed in 721_B
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P25205
Other Accession NM_002388, NP_002379
Reactivity Human, Mouse, Rat, Rabbit, Horse, Yeast, Bovine, Dog
Predicted Human, Mouse, Rat, Chicken, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 91kDa
Additional Information
Gene ID 4172
Alias Symbol HCC5, MGC1157, P1-MCM3, P1.h, RLFB
Other Names DNA replication licensing factor MCM3, 3.6.4.12, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, MCM3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-MCM3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMCM3 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCM3 (HGNC:6945)
Function Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable).
Cellular Location Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
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References

Lin,D.I., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (23), 8079-8084 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 389.00
Cat# AI11009
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