KIN antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O60870 |
Other Accession | NM_012311, NP_036443 |
Reactivity | Human, Mouse, Rat, Horse, Bovine, Dog |
Predicted | Human, Mouse, Rat, Chicken, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 45kDa |
Gene ID | 22944 |
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Alias Symbol | BTCD, KIN17 |
Other Names | DNA/RNA-binding protein KIN17, Binding to curved DNA, KIN, antigenic determinant of recA protein homolog, KIN (HGNC:6327), BTCD, KIN17 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 100 ul of distilled water. Final anti-KIN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | KIN antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KIN (HGNC:6327) |
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Synonyms | BTCD, KIN17 |
Function | Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. |
Cellular Location | Nucleus. Cytoplasm. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485} |
Tissue Location | Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis Differentially expressed in non-tumorigenic and tumorigenic cell lines Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
References
le Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62 (PTReconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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