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Anti-PAX8 (Renal Cell Marker) Antibody

Mouse Monoclonal Antibody

     
  • WB - Anti-PAX8 (Renal Cell Marker) Antibody AH13584-20
    Western Blot Analysis (A) Recombinant Protein (B) Raji Cell Lysate Using PAX8 Monoclonal Antibody (PAX8/1492).
    detail
  • IHC-P - Anti-PAX8 (Renal Cell Marker) Antibody AH13584-20
    Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with PAX8 Monoclonal Antibody (PAX8/1492).
    detail
  • IHC-P - Anti-PAX8 (Renal Cell Marker) Antibody AH13584-20
    Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with PAX8 Monoclonal Antibody (PAX8/1492).
    detail
  • IHC-P - Anti-PAX8 (Renal Cell Marker) Antibody AH13584-20
    Formalin-fixed, paraffin-embedded human Urothelial Carcinoma stained with PAX8 Monoclonal Antibody (PAX8/1492).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, FC
Primary Accession Q06710
Other Accession 469728
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a
Clone Names PAX8/1492
Calculated MW 48218 Da
Additional Information
Gene ID 7849
Other Names Paired box 8; Paired box gene 8; paired box homeotic gene 8; Paired box protein Pax-8; Paired domain gene 8; PAX8
Application Note Flow Cytometry (0.5-1ug/million cells); ,Immunofluorescence (1-2ug/ml); ,Western Blotting (0.5-1ug/ml); ,Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
PrecautionsAnti-PAX8 (Renal Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX8
Function Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
Cellular Location Nucleus.
Tissue Location Expressed in the excretory system, thyroid gland and Wilms tumors
Research Areas
Citations (0)
citation

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Background

Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

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$ 219.00
$ 499.00
Cat# AH13584-20
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