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Anti-Galectin-13 (GAL13) / Placental Protein 13 (PP13) Antibody
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, FC, E |
|---|---|
| Primary Accession | Q9UHV8 |
| Other Accession | 23671 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG2b |
| Clone Names | PP13/1164 |
| Calculated MW | 16119 Da |
| Gene ID | 29124 |
|---|---|
| Other Names | Gal-13; GAL13; Galactoside-binding soluble lectin 13; Galectin-13; Galectin13; Lectin galactoside binding soluble 13; LGALS13; PLAC8; Placental protein 13 (PP13); Placental tissue protein 13 |
| Application Note | ELISA (For coating, order Ab without BSA);Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (0.5-1ug/ml);Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 or 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined. |
| Format | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Anti-Galectin-13 (GAL13) / Placental Protein 13 (PP13) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LGALS13 |
|---|---|
| Synonyms | PLAC8 |
| Function | Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis (PubMed:10527825, PubMed:19497882). Has hemagglutinating activity towards chicken erythrocytes (PubMed:29343868). |
| Cellular Location | Cytoplasm. Nucleus matrix |
| Tissue Location | Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast |
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Provided below are standard protocols that you may find useful for product applications.
Background
It recognizes a 32kDa protein, which is identified as homodimer of galectin-13 (also known as PP13). Galectins are a family of soluble β-galactoside-binding lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) interactions and play a role in tumor progression, pre-mRNA splicing and apoptosis. One such member, galectin-13, is a 139 amino acid protein that contains one galectin domain. Possessing lysophospholipase activity, galectin-13 exists as a disulfide-linked homodimer. Galectin-13 is suggested to have a developmental role in the placenta and may display immunobiological activity in feto-maternal blood-spaces. Screening for galectin-13 in maternal serum during the first trimester of pregnancy may serve as a diagnostic marker to predict preterm pre-eclampsia.
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