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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Cytokine   >    CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody - With BSA and Azide   

CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone TNFS7/1026 ]

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-F, IF, FC, E, IP
Primary Accession P32970
Other Accession 970, 501497, 715224
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names TNFS7/1026
Calculated MW 30kDa
Additional Information
Gene ID 970
Other Names CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD70 (HGNC:11937)
Function Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, PubMed:28011864, PubMed:8387892). The CD70- CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864).
Cellular Location Cell membrane; Single-pass type II membrane protein
Research Areas
Citations (0)
citation

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Background

It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis.

References

Lens, S.M., et al. 1995. CD27-CD70 interaction: unravelling its implication in normal and neoplastic B cell growth. Leuk. Lymphoma 18: 51-59

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$ 219.00
$ 499.00
Cat# AH12802-20
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