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CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone BU69 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-F, IF, FC, E, IP |
|---|---|
| Primary Accession | P32970 |
| Other Accession | 970, 501497, 715224 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | BU69 |
| Calculated MW | 30kDa |
| Gene ID | 970 |
|---|---|
| Other Names | CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD70 (HGNC:11937) |
|---|---|
| Function | Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, PubMed:28011864, PubMed:8387892). The CD70- CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown toĀinhibit T cell proliferation induced by dendritic cells.
References
R.Q. Hintzen, et al, (1994) J Immunol 152: 1762-1773. | M.R. Bowman, et al, (1994) J Immunol 152: 1756-1761. | Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138. | K. Agematsu, et al, (1995) J Immunol 154: 3627-3635
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