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CD20 / MS4A1 (B-Cell Marker) Antibody - Culture Supernatant

Mouse Monoclonal Antibody [Clone L26 + IGEL/773 ]

     
  • IHC -  CD20 / MS4A1 (B-Cell Marker) Antibody - Culture Supernatant  AH12667-01
    Formalin-fixed, paraffin-embedded human Tonsil stained with CD20 Monoclonal Antibody (L26 + IGEL/773)
    detail
  • IHC -  CD20 / MS4A1 (B-Cell Marker) Antibody - Culture Supernatant  AH12667-01
    Formalin-fixed, paraffin-embedded human Lymphoma stained with CD20 Monoclonal Antibody (L26 + IGEL/773)
    detail
  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession P11836
Other Accession 931, 712553
Reactivity Human, Monkey, Baboon
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG's
Clone Names L26 + IGEL/773
Calculated MW 33-37kDa
Additional Information
Gene ID 931
Other Names B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD20 / MS4A1 (B-Cell Marker) Antibody - Culture Supernatant is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MS4A1
Synonyms CD20
Function B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor. Note=Constitutively associated with membrane rafts.
Tissue Location Expressed on B-cells.
Research Areas
Citations (0)
citation

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Background

Recognizes a protein of 30-33kDa, which is identified as CD20. Its epitope is located in the cytoplasmic domain of CD20 and was, therefore, ascribed as CD20cy in the 5th Workshop. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkinā€™s disease, particularly of lymphocyte predominant type.

References

Schlossman, S., et al., eds. 1995. Leucocyte Typing V. New York: Oxford University Press

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$ 199.00
$ 429.00
Cat# AH12667-01
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