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CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone 66IIC7 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P06126 |
| Other Accession | 909, 1309 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG2a, kappa |
| Clone Names | 66IIC7 |
| Calculated MW | 49kDa |
| Gene ID | 909 |
|---|---|
| Other Names | T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1a, CD1A |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD1A |
|---|---|
| Function | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Note=Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838). |
| Tissue Location | Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).Ā
References
van de Rijn M et al. J Immunol 1983, 131(2):851-5 | Lerch PG et al. Hum Immunol 1983, 6(1):13-30 | Knapp W. et al. (eds) Leukocyte Typing IV, p251-263, Oxford University Press, Oxford, 1989 | Khalili-Shirazi A, et al. J Neurol Sci 1998,158(2):154-163. | Maher JK and Kronenberg M.. Curr Opin Immunol 1997, 9(4):456-461 | Blumberg RS et al. Immunol Rev 1995, 147:5-29. | Salamone MC et al. Dis Markers 1990, 8(5):275-281
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