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Vimentin (Mesenchymal Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone LN-6 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, FC |
|---|---|
| Primary Accession | P08670 |
| Other Accession | 7431, 455493 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Bovine, Sheep, Cat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgM |
| Clone Names | LN-6 |
| Calculated MW | 57-60kDa |
| Gene ID | 7431 |
|---|---|
| Other Names | Vimentin, VIM |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Vimentin (Mesenchymal Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VIM (HGNC:12692) |
|---|---|
| Function | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix {ECO:0000250|UniProtKB:P31000}. Cell membrane {ECO:0000250|UniProtKB:P20152} |
| Tissue Location | Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This MAb reacts with a 58kDa protein identified as vimentin. It reacts with a non-hematopoietic epitope of vimentin and shows no cross-reaction with other closely related intermediate filament proteins (IFPā€™s) such as desmin, keratin, neurofilament, and glial fibrillary acid protein.ĀVimentin is ubiquitously expressed in mesenchymal cells such as fibroblasts, smooth muscle cells, and endothelium. Antibody against vimentin is useful as part of an antibody panel for differential diagnosis of tumors of unknown origin.ĀAb-2 does not react with leukocyte common antigen-positive tissues such as lymphomas and leukemias.
References
Stathopoulos, E., et al., J. Histochem. Cytochem. 37, 1363 (1989)
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