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GRP94 / HSP90B1 (Endoplasmic Reticulum Marker) Antibody - With BSA and Azide

Rat Monoclonal Antibody [Clone HSP90B1/1192 ]

     
  • IHC -  GRP94 / HSP90B1 (Endoplasmic Reticulum Marker) Antibody - With BSA and Azide AH12459-20
    Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with GRP94 Monoclonal Antibody (HSP90B1/1192).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, FC
Primary Accession P14625
Other Accession 7184, 192374
Reactivity Human
Host Rat
Clonality Monoclonal
Isotype Rat / IgG2a, kappa
Clone Names HSP90B1/1192
Calculated MW 94kDa
Additional Information
Gene ID 7184
Other Names Endoplasmin, 94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog, HSP90B1, GRP94, TRA1
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions GRP94 / HSP90B1 (Endoplasmic Reticulum Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSP90B1 (HGNC:12028)
Function Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059).
Cellular Location Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P41148}. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Research Areas
Citations (0)
citation

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Background

Recognizes a protein of 94kDa, which is identified as the glucose-regulated protein 94 (grp94) and also tumor rejection antigen (gp96). Grp94 shows a high degree of sequence homology with the heat shock protein 90 (hsp90). This MAb is highly specific to grp94 and shows minimal cross-reaction with other members of the HSP90 family. Grp s are a class of proteins unresponsive to heat shock and are induced by glucose deprivation. Grp94 has been briefly studied as a prognostic factor in breast cancer.

References

Sorger, P.K. et al. J. Mol. Biol. 194: 341-344 (1987). | Tandon, A.K. et.al. Breast Cancer Res. and Treat. 16: 146 (1990). |

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$ 219.00
$ 499.00
Cat# AH12459-20
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