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Retinol Binding Protein-1 (RBP1) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone RBP/872 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF |
|---|---|
| Primary Accession | P02753 |
| Other Accession | 5947, 5948, 5950, 529571, P09455, P50120 |
| Reactivity | Human, Mouse, Rat, Rabbit, Monkey, Goat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | RBP/872 |
| Calculated MW | 21-25kDa |
| Gene ID | 5950 |
|---|---|
| Other Names | Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Retinol Binding Protein-1 (RBP1) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBP4 |
|---|---|
| Function | Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood plasma and in urine (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Recognizes a protein of 21kDa-25kDa, identified as retinol binding protein-1 (RBP1). This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein post-transnationally and results in defective delivery and supply to the epidermal cells.
References
Naylor, H.M., et al. 1999. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy-terminus of RBP. Biochemistry 38: 2647-2653
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