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MUC5AC (Mucin 5AC / Gastric Mucin) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone 58M1 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P98088 |
| Other Accession | 4586, 534332 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | 58M1 |
| Calculated MW | >1,000kDa |
| Gene ID | 4586 |
|---|---|
| Other Names | Mucin-5AC, MUC-5AC, Gastric mucin, Lewis B blood group antigen, LeB, Major airway glycoprotein, Mucin-5 subtype AC, tracheobronchial, Tracheobronchial mucin, TBM, MUC5AC, MUC5 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | MUC5AC (Mucin 5AC / Gastric Mucin) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MUC5AC {ECO:0000303|PubMed:11535137, ECO:0000312|HGNC:HGNC:7515} |
|---|---|
| Function | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). |
| Cellular Location | Secreted |
| Tissue Location | Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC).Ā Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
References
Cancer Res.46: 3983-3989 (1986). | Biochem. J. 254: 185-193 (1988). | Int. J. Cancer 47: 304-310 (1991). | J. Immunol. Methods 149: 105-113 (1992
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