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MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone 2F6 ]

     
  • IHC -  MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody - With BSA and Azide AH11803-20
    Formalin-fixed, paraffin-embedded human Uterine Carcinoma stained with MAP3K1 Monoclonal Antibody (2F6).
    detail
  • IHC -  MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody - With BSA and Azide AH11803-20
    Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with MAP3K1 Monoclonal Antibody (2F6).
    detail
  • IHC -  MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody - With BSA and Azide AH11803-20
    Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with MAP3K1 Monoclonal Antibody (2F6).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, FC
Primary Accession Q13233
Other Accession 4214, 653654
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names 2F6
Calculated MW 195kDa (intact); 80kDa (cleaved)
Additional Information
Gene ID 4214
Other Names Mitogen-activated protein kinase kinase kinase 1, 2.7.11.25, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1, MAP3K1, MAPKKK1, MEKK, MEKK1
Format 10mM PBS with 0.05% BSA & 0.05% azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K1
Synonyms MAPKKK1, MEKK, MEKK1
Function Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).
Research Areas
Citations (0)
citation

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Background

Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NFĪŗB pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.

References

Guan, K.L. 1994. The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. Cell. Signal. 6: 581-589

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$ 219.00
$ 499.00
Cat# AH11803-20
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