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CD46 (Membrane Cofactor Protein) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone 169-1-E4.3 ]

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IF, FC
Primary Accession P15529
Other Accession 4179, 510402
Reactivity Human, Baboon
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names 169-1-E4.3
Calculated MW 52-58kDa
Additional Information
Gene ID 4179
Other Names Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, CD46, MCP, MIC10
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD46 (Membrane Cofactor Protein) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD46
Synonyms MCP, MIC10
Function Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Cellular Location Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide
Tissue Location Expressed by all cells except erythrocytes.
Research Areas
Citations (0)
citation

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Background

Recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

References

Sparrow et al. Human Immunol 7, 115 (1983). | Purcell et al. Immunol Cell Biol 67, 279289 (1989). | Cho et al. Clin Exp Immunol 83, 257261 (1991). | Purcell et al. Immunol 70, 155161 (1990)

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$ 219.00
$ 499.00
Cat# AH11798-20
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